Immunofluorescence studies on the skin sections of recessive dystrophic epidermolysis bullosa patients with anti-P_ (200) pemphigoid sera / 中国免疫学杂志
Chinese Journal of Immunology
;
(12)1999.
Artigo
em Chinês
| WPRIM
| ID: wpr-538840
ABSTRACT
Objective:
In order to determine the nature of P 200 autoantigenMethods:
12 cases of anti-P 200 pemphigoid sera were collected The skin sections from 6 cases of recessive dystrophic epidermolysis bullosa were studied with these sera by indirect immunofluorescenceResults:
All the 12 anti-P 200 pemphigoid sera could react with basement membrane zone (BMZ)of 5 cases of recessive dystrophic epidermolysis bullosa, while epidermolysis bullosa acquisita sera were negative in these skins In addition, in a case of recessive dystrophic epidermolysis bullosa, epidermolysis bullosa acquisita sera react with both BMZ and intracytoplasmic deposition of type Ⅶ collagen, while no anti-P 200 pemphigoid sera showed this reactivityConclusion:
These results suggested that the 200 kD antigen is not a component of type Ⅶ collagen, but a specific autoantigen
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Immunology
Ano de publicação:
1999
Tipo de documento:
Artigo
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