Anticaries potential of salivary gland extract / 实用口腔医学杂志

ABSTRACT

Objective: To study the anticaries effects of salivary gland extract (SGE). Methods: Dental caries model was established in 80 SD rats by feeding with cariogenic diet 2000 and by infecting with cariogenic bacteria. 20 model rats in each of the 4 experimental group were fed with SGE at 400 mg/kg, 1 500 mg/kg or 5 mg/L of NaF or deionic water respectively,another 20 were fed with ordinary diet as blank control. The anticaries effects were evaluated by Keyes caries scores, SOD activity in blood cells was determined by NBT test. The effect of SGE on dissoluble Ca 2+ from teeth was determined in electrochemical artificial caries model in vitro. Results: caries was not observed in the blank control. According to Keyes caries score, at E, Ds, Dm and Dx levels, the score in SGE groups was significantly lower than that in the model group (P0.05). SGE obviously enhanced SOD activity (P