Protective effect of Ginkgo biloba extract on acute lung injury in aging rats and renal function damage induced by acute lung injury / 中华老年医学杂志

ABSTRACT

Objective To investigate whether gingko biloba extract (GBE) have protective effect on acute lung injury(ALI)induced by Lipopolysaccharide ( LPS) in aging rats and renal function damage induced by ALI. Methods Male aging Wistar rats(36) were used in the study. LPS group (LPS, iv route, 5mg/kg body weight) and GBE+LPS group (GBE was given starting from 7 days before experiment, once a day oral administration). The blood, lung and kidney samples were collected at 2 or 6 hours after LPS or saline administration. Results Compared with the aging control, ALI was obviously observed in LPS group, blood creatinine and urea nitrogen were increased significantly from (68.7? 6.9) mol/L and (5.9?0.6) mmol/L to (94.7?10.3) mol/L and (11.4?1.9) mmol/L, respectively (P