Protective effect of sivelestat sodium on ischemia reperfusion brain injury in rats / 重庆医科大学学报
Journal of Chongqing Medical University
; (12)2003.
Article
em Zh
| WPRIM
| ID: wpr-539727
Biblioteca responsável:
WPRO
ABSTRACT
Objective:To explore the protective effect of sivelestat sodium on cerebral ischemia reperfusion in rats and its mechanism.Methods:The neurons of neonate rat were cultured in vitro.The protective effects of sivelestat sodium on ischemia injury were observed by treating cells in glucose-free and oxygen-free medium.Results:Sivelestat sodium(10-8、10-7 and 10-6mol/L)increased the activity of neurons,reduced the leakage rate of LDH,increased the activity of SOD and reduced the content of MDA.Conclusion:sivelestat sodium protects the neurons against ischemia injury by suppressing the generation of lipid peroxide.
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WPRIM
Idioma:
Zh
Revista:
Journal of Chongqing Medical University
Ano de publicação:
2003
Tipo de documento:
Article