A Case of Myelodysplastic Syndrome in a Renal Transplant Recipient / 대한신장학회잡지
Korean Journal of Nephrology
;
: 204-209, 1999.
Artigo
em Coreano
| WPRIM
| ID: wpr-54005
ABSTRACT
A 44-year-old man treated with azathioprine, cyclosporine and prednisolone for 7.5 years after allogeneic renal transplantation was admitted because of exertional dyspnea, fatigue and pancytopenia which were found 3 months ago. He had been on hemodialysis for renal failure of unknown cause for 8 months before the renal transplantation. Bone marrow examination showed hypercellularity, erythroid hyperplasia and 7% of myeloblast, consistent with the diagnosis of myelodysplastic syndrome. Cytogenetic study showed chromosomal abnormalitiesdeletion of chromosome 5, monosomy 7, trisomy 8, monosomy 14 and deletion of chromosome 17. Immunosuppressive agents were discontinued and he was treated with transfusion, G-CSF, and combination chemotherapy including topotecan and Ara-C. Graft kidney function was normal before and after the treatment, but the clinical course was fatal because of leukemic transformation and eventually sepsis. Although therapy induced myelodysplastic syndrome was rare in renal allograft recipients, thorough evaluations including bone marrow biopsy and cytogenetic study are recommended in patients with anemia of unknown etiology.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pancitopenia
/
Azatioprina
/
Transplante
/
Trissomia
/
Biópsia
/
Medula Óssea
/
Exame de Medula Óssea
/
Síndromes Mielodisplásicas
/
Cromossomos Humanos Par 5
/
Cromossomos Humanos Par 17
Tipo de estudo:
Estudo diagnóstico
Limite:
Adulto
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Nephrology
Ano de publicação:
1999
Tipo de documento:
Artigo
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