A kinetic study on the relationship between IL-5,sIL-2R and eosinophil apoptosis in asthmatic patient's airway inflammation / 中国免疫学杂志
Chinese Journal of Immunology
;
(12)2000.
Artigo
em Chinês
| WPRIM
| ID: wpr-540154
ABSTRACT
Objective:
To explore the relationship between eosinophil(EOS) and IL-5,sIL-2R in asthmatic patients in sputum.Methods:
Thirty asthmatic patients (asthmatic group) during exacerbation and stable stage and twenty healthy persons were selected.IL-5 and sIL-2R in sputum were determined by ELISA ,EOS apoptosis was identified by flow cytometre.Results:
IL-5 ,sIL-2R and EOS apoptosis percentages in the patients during exacerbation and stable stage in sputum were increased significantly,.There were no expression of EOS apoptosis in the healthy persons. Data analyses revealed a negative correlation between EOS apoptosis and the levels of IL-5, and a closer correlation between the percentages and IL-5.Conclusion:
EOS underwent apoptosis in asthmatic airway and EOS apoptosis was regulated by IL-5.There were no correlation between EOS apoptosis and sIL-2R.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Immunology
Ano de publicação:
2000
Tipo de documento:
Artigo
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