Screening for Mutations of MODY 1-5 Genes in Chinese Families with Early-onset Type 2 Diabetes / 中山大学学报(医学科学版)
Journal of Sun Yat-sen University(Medical Sciences)
;
(6): 437-440,封3, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-540593
ABSTRACT
[Objective] The aim of our study was to seek the mutations in MODY1~5 genes in Chinese population by direct sequencing in probands from families with early-onset type 2 diabetes.[Methods] Variants screening in MODY 1-5 genes were performed by PCR and direct sequencing in 19 probands from early-onset type 2 diabetes families.[Results] We found no mutation but many polymorphisms.There were 6,5,15,1,and 1 variants in MODY 1-5 genes respectively.[Conclusion] Our negative results in MODY genes suggest the genetic heterogeneity of different populations.Mutations in MODY 1-5 genes might not be the cause of diabetes in those 19 families.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo diagnóstico
/
Estudo de rastreamento
Idioma:
Chinês
Revista:
Journal of Sun Yat-sen University(Medical Sciences)
Ano de publicação:
2009
Tipo de documento:
Artigo
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