Spatial and temporal features of proliferating vessels during mandibular distraction osteogenesis / 实用口腔医学杂志

ABSTRACT

Objective:To study the spatial and temporal features of p roliferating vessels during mandibular distraction osteogenesis. Methods:Bilateral mandibles of twelve adult goats were lengthened by 10 mm wit h a custom-made distractor at 1 mm/d, two animals were killed at each intervals . Two additional goats were used as normal control. SEM microvascular corrosion casting was used to examine the spatial and temporal features of proliferative v essels within distraction gap. Results:During distraction perio d, numerous vessels from bone marrow and periosteum were regenerated into distra ction gap and began to form vascular network. In the early phase of fixation per iod, the orientation of vein sinus was in accord with distraction orientation. A long with the time, more vessles were connected, regeneration of vessels vanishe d, and the vascular system within distraction gap became more mature.Con clusionAngiogenesis during DO is closely related to the osteogenesis; the blood supply of new bone in distraction gap is from both bone marrow and per iosteum.