Inhibiting effect of HLA-derived peptide on immune function of rat splenocytes / 中国免疫学杂志
Chinese Journal of Immunology
; (12)1985.
Article
em Zh
| WPRIM
| ID: wpr-541333
Biblioteca responsável:
WPRO
ABSTRACT
Objective: To study the immunosuppression function of a novel HLA-derived pepride, RDP1258,and it' s mechanisms. Methods:A peptide derived from HLA,RDP1258,was chemically synthesized.The effects of the peptide on alloreactive cytotoxic activities of rat splenocytes were observed using 3H-TdR method.The heme oxygenase-1(HO-1) activity was analyzed by the enzyme chemistry method.Results:The results showed that the synthetic HLA-derived peptide can obviusly inhibit the proliferation of rat splenocytes and the peptide inhibited HO-1 activty in a dose-dependment manner in vitro.Conclusion:HO-1 might participate in the RDP1258 inhibiting the proliferation of rat splenocytes induced by mitogen and isoantigen.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Immunology
Ano de publicação:
1985
Tipo de documento:
Article