Experimental study on blood perfusion of acute rejection in renal allograft with ultraharmonic contrast imaging / 中华超声影像学杂志

ABSTRACT

Objective To evaluate the value of using ultraharmonic contrast imaging(UHCI) and acoustic densitometry(AD) technique to quantify cortex blood perfusion of acute rejection in renal allograft.Methods The canine models with acute renal allograft rejection were established. The examinations of renal allograft were performed by intravenous contrast ultrasound and AD technique on the days 1,3,5,7,9,11 after transplantation,some parameters related to perfusion such as peak intensity(PI),the area under the curve(AUC),the half time of descending(HT) and the mean transit time(MTT) of renal cortex were measured,and the graft biopsies were done simultaneously.Results The cortex of renal allograft with acute rejection showed nonenhancing defects after contrast agent injection. From 5 to 11 days after transplantation,the PI,AUC,HT,MTT of renal cortex were increasingly decreased,and the 50% wash-out slope was increasingly increased; furthermore,there were significant differences between those of the first day of post-operation(P