Clinicopathological characritics and prognosis of large intestinal mucoid adenocarcinoma / 中国癌症杂志

ABSTRACT

Purpose:To investigate the clinicopathological characristics of colorectal mucinous adenocarcinoma (MUC),which is generally bel ieved to have a poor prognosis,in an attempt to assess ways in which the surgica l outcome can be improved. Methods:From 1994 to 2003,1 715 large intestinal cancer patient s underwent operation, among them, 197 patients were with MUC. The clinicopathol ogical parameters and prognosis of MUC and non-MUC were analyzed retrospectivel y. Results:There were no significant differences in sex , tumor si te and size. Patients with MUC had higher rate of serosal invasion (MUC59.9% vs non-MUC 35.1%) , invasive type lymph-node involvement (MUC41.6% vs non-MUC 21.6%). Patients with MUC were of more advanced stage(D stageMUC44.1% vs non-MUC 22.1%). Conclusions:Based on these findings , a more aggressive attitud e toward surgical intervention is recommended , including extensive lymph node d issection and the resection of adjacent organs that seems to be affected microsc opically , to improve the surgical outcome of this clinical entity.