Loss of hetrozygosity of p53 gene and p53 gene mutation in esophageal squamous cell carcinoma / 肿瘤研究与临床

ABSTRACT

0.05). The positive rate was 81.0 %(17/21) in those with lymph node metastasis vs 48.6 %(17/35) in those without lymph node metastasis. The 3 year survival rate with p53 protein expression was significantly lower than those without p53 protein expression. [46.4 %(13/28) and 73.9 %(17/23) respectively]. The LOH rate of p53 gene in ESCC was 80.5 %(33/41), which had no obvious correlation with Age,Sex, Family history and lymph node metastasis, but had obvious correlation with the 3 year survival rate(P