The effect of intra-articular ligustrazine injection on degenerative cartilage of the rabbit's knee / 西安交通大学学报(医学版)

ABSTRACT

Objective To observe the effects of ligustrazine intra-articular injection on cartilage degeneration in OA.To estimate and discuss the vistas of clinical application with ligustrazine intraarticular injection.(Methods)26 New Zealand white rabbits were randomly divided into 4 groups,2 rabbits in normal group,8 rabbits in model,control and experimental group,respectively.OA animal model was established in rabbits by the way of fixing right posterior knee joint with plaster cast in strecthing state in model,control and experimental group.(0.3mL) ligustrazine intra-articular injection was carried out once a week in experimental group.(0.3mL) dexamethasone in the same way was made in control group.At 6 week and 9 weeks later,optic and electron microscopic examinations were conducted to observe the pathological changes of articular cartilage of the knee of these animals.Results There was a significant difference in Mankin scale between experimental group and 3 other groups((P0.05)),and between these 2 groups the electro microscopic observation was similar.Conclusion Intra-articular injection of ligustrazine can alleviate degeneration and promote self-reparation of articular cartilage.Method of intra-articular injection of cortisocteroid has no reparation effect on OA cartilage(degeneration).