Clearance of tetrandrine from vitreous / 眼科

ABSTRACT

The pharmacokineties of intravitreally injected tetrandrine was monitered by high-performance liquid chromatography (HPLC). After intravitreal injection of tetrandrine in rabbits' eyes, aqueous humor and vitreous were drawn at different times for determination. The drug concentration in the aqueus humor and vitreous was measured by HPLC. The results showed that the concentration-time curves of tetr-andrinc in the vitreous fitted in with a two-compar-tment open model with half-life periods of 1.02 hour(?) and 16.62 hour (?) respectively. The drug concentration in aqueous humor was low, with a peak value of 6.73?g/ml at two hour.