Effect of mild hypothermia on serum cytokines levels in patients with severe brain injury / 中华创伤杂志

ABSTRACT

Objective To explore the effect of mild hypothermia on tumor necrosis factor alpha (TNF-?),interleukin-1?(IL-1?),interleukin-6 (IL-6) and interleukin-8 (IL-8) in serum of patients with severe traumatic brain injury and its clinical significance. Methods Mild hypothermia was used within 24 hours after injury to keep the rectal temperature at 33℃-35℃ for five days in 23 patients, who suffered from severe brain injury with GCS score of 3-8 (mild hypothermia group). And 21 patients who suffered from severe brain injury with GCS score of 3-8 were taken as control group. The dynamic changes of serum TNF-?, IL-1?, IL-6 and IL-8 at days 1, 2, 3 and 4 respectively after trauma were monitored using ELISA. Results Levels of serum TNF-?, IL-1?, IL-6 and IL-8 were decreased more significantly in the mild hypothermia group than those in the control group(P