The clinical implications of acquired thrombophilia in patients with ovarian hyperstimulation syndrome / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
;
: 744-749, 2008.
Artigo
em Coreano
| WPRIM
| ID: wpr-54309
ABSTRACT
OBJECTIVE:
To investigate the clinical significance of thrombophilia in patients admitted with ovarian hyperstimulation syndrome (OHSS).METHODS:
Twenty-five infertile women who were admitted into university hospital due to OHSS after ovarian hyperstimulation for intrauterine insemination or in vitro fertilization. Blood samples were drawn at the time of admission and three thrombophilic factors were assayed; antithrombin III, protein C and protein S. Subjects were divided into severe (n=18) and mild-to-moderate (n=7) OHSS, and laboratory parameters including three thrombophilic factors were compared.RESULTS:
Antithrombin III level was abnormal in 40% of subjects, protein C in 12%, and protein S in 72%. There was no significant difference in the laboratory parameters between the patients with normal (n=15) and abnormal antithrombin III levels (n=10). However, the patients with abnormal antithrombin III levels had significantly more severe OHSS than those with normal value (100% vs 55.6%, P=0.013). The patients with at least one abnormal thrombophilic factor had significantly more severe OHSS than those with all normal value (94.4% vs 42.9%, P=0.012).CONCLUSIONS:
Thrombophilic factors, particularly antithrombin III, may be associated with disease severity in patients with OHSS.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Valores de Referência
/
Proteína C
/
Fertilização in vitro
/
Antitrombina III
/
Síndrome de Hiperestimulação Ovariana
/
Proteína S
/
Trombofilia
/
Inseminação
Limite:
Feminino
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Obstetrics and Gynecology
Ano de publicação:
2008
Tipo de documento:
Artigo
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