Inhibition of bladder activity by 5-HT1 subtype-selective serotonin receptor agonists in cats with chronic spinal cord injury / 中华泌尿外科杂志
Chinese Journal of Urology
;
(12)2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-544401
ABSTRACT
Objective To investigate the effect of bladder activity by 5-hydroxytryptamine serotonin receptor agonists with chronic spinal cord injury(SCI). Methods Intact cats and SCI cats were catheterized through the bladder dome for saline-filling cystometry.Dose-response curves for i.v.8-OH-DPAT and GR-46611 were followed in three cases each by WAY-100635.Threshold volume,capacity,residual volume,micturition volume,and arterial pressure were measured. Results Intact cats showed few significant changes in cystometric variable.SCI cats responded to both 8-OH-DPAT and GR-46611 with dose-dependent increases in threshold volume,capacity,and residual volume.Effects of 8-OH-DPAT but not GR-46611 were largely reversed by WAY-100635. Conclusions Both 5-HT_ 1A and 5-HT_ 1B/1D agonists may offer a promising means of reducing bladder hyperactivity and increasing bldder capacity in patients with chronic SCI.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Urology
Ano de publicação:
2006
Tipo de documento:
Artigo
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