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The study on inhabitory effects of chitosan oligosaccharide on tumor growth in vivo and in vitro / 中国免疫学杂志
Chinese Journal of Immunology ; (12)1985.
Artigo em Chinês | WPRIM | ID: wpr-545002
ABSTRACT

Objective:

To investigate the inhibitory effects of chitosan oligosaccharide on tumor growth in vivo.

Methods:

Murine tumor cell line H22 was inoculated into. Then different doses of chitosan oligosaccharide were injected into the mice-bearing H22 liver carcinoma, IL-2 and IFN-? in the sera were measured by ELISA assay. The in vitro anti-proliferation activity of chitosan oligosaccharide on the lung carcinoma LH-7 cells was evaluated by MTT assay.

Results:

Chitosan oligosaccharide inhibited in vivo the growth of H22 tumor cells,with increasing the content of IL-2 and IFN-? in sera of the tumor-bearing mice. The weight of spleen and thymus of the mice were increased when compared with those of control group; tissue necrosis was observed in the tumor in situ; chitosan oligosaccharide also inhibited the growth of LH-7 cells in vitro. The inhibitory effect was shown in a concentration dependent pattern, but not correrlated with incubation time. The early characteristics of apoptosis of LH-7 cell could be observed under the transmission electronic microscopy.

Conclusion:

Chitosan oligosaccharide inhibits proliferation of tumor and improves immunity function of the hosts, and might induce apoptosis of LH-7 cells.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Immunology Ano de publicação: 1985 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Immunology Ano de publicação: 1985 Tipo de documento: Artigo