A case of levocetirizine-induced liver injury
Clinical and Molecular Hepatology
;
: 495-498, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-54508
ABSTRACT
Levocetirizine is a second-generation nonsedative antihistaminic agent that has been demonstrated to be safe and effective for treating allergic disease. There was only one case report of levocetirizine-induced liver toxicity, but a liver biopsy was not performed. In this article, we present the first case of levocetirizine-induced liver injury with histologic findings. A 48-year-old man was hospitalized with jaundice and generalized pruritus that had developed after 2 months of therapy with levocetirizine for prurigo nodularis. Laboratory findings revealed acute hepatitis with cholestasis. A liver biopsy demonstrated portal inflammation and hepatitis with apoptotic hepatocytes. The patient fully recovered 3 weeks after withdrawing levocetirizine. Although levocetirizine is safe and effective, physicians should be aware of its potential hepatotoxicity.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prurido
/
Cetirizina
/
Antagonistas não Sedativos dos Receptores H1 da Histamina
/
Doença Hepática Induzida por Substâncias e Drogas
/
Hipersensibilidade
/
Icterícia
/
Fígado
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Clinical and Molecular Hepatology
Ano de publicação:
2016
Tipo de documento:
Artigo
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