The Effect of Vasodilators on the Cerebral Vasospasm Induced by Experimntal Subarachnoid Hemorrhage
Journal of Korean Neurosurgical Society
;
: 875-886, 1988.
Artigo
em Coreano
| WPRIM
| ID: wpr-54520
ABSTRACT
This paper notes the effect of vasodilators on the cerebral vasospasm induced by experimental subarachnoid hemorrhage. Artificial subarachnoid hemorrhage produced by dual injection of non-heparinized autologous blood into the cisterna magna in rabbits with 72 hours interval gave rise to considerable narrowing or spasm of the basilar artery and its branches demonstrated by cerebral angiography. SAH was induced in 12 rabbits by injecting 1.3mL/kg or autologous fresh arterial blood into the cisterna magna, followed by suspending the rabbits in a head-down position at 30 degree for 1 hour in order to accumulate blood around the basilar artery. The animals were divided into 4 groups; a group receiving nifedipine, a group receiving aminophylline, a group receiving papaverine, a group receiving trifluoperazine HCl. Angiographically vertebrobasilar arterial spasm was demonstrated 3 days after the 2nd autologous blood injection into the cisterna magna. Radiographically visible spasm was resistant to the vasodilating drugs. Rabbits were sacrificed by the overdose injection of sodium phenobarbital at the end of experiment.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Papaverina
/
Fenobarbital
/
Sódio
/
Espasmo
/
Hemorragia Subaracnóidea
/
Trifluoperazina
/
Vasodilatadores
/
Artéria Basilar
/
Angiografia Cerebral
/
Angiografia
Limite:
Animais
Idioma:
Coreano
Revista:
Journal of Korean Neurosurgical Society
Ano de publicação:
1988
Tipo de documento:
Artigo
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