Expression of Lumican mRNA in Gastric Cancer and Its Clinical Significance / 中国普外基础与临床杂志

ABSTRACT

Objective To investigate the expression of tumor suppressor gene Lumican mRNA in gastric cancer and its role in the development of gastric cancer.Methods The expressions of Lumican mRNA in gastric cancer tissues,tissues near tumor and normal tissues were detected by using reverse transcription polymerase chain reaction(RT-PCR),clinical pathology for those tissues was studied as well.Results The expression absence rates of Lumican mRNA were 42.4%(28/66),15.2%(10/66)and 0 in gastric cancer tissues,tissues near tumor and normal tissues respectively.The expression absence rate of Lumican mRNA in patients with lymph node metastasis was 61.1%,which was significantly higher than that of the patients without lymph node metastasis(20.0%,?2=11.323,P=0.001).The expression absence rate of Lumican mRNA in the gastric cancer at the advanced stages(stages Ⅲ,Ⅳ)was 61.5%,which was significantly higher than that in the gastric cancer at the early stages(stages Ⅰ,Ⅱ,30.0%,?2=6.417,P=0.011).The expression absence rates of Lumican mRNA in the high,moderate and poor differentiation tumors were 38.5%(10/26),38.5%(10/26)and 57.1%(8/14)respectively,the expression absence rate of Lumican mRNA was no significant association with the differentiation degree(?2=1.576,P=0.455).Conclusion The expression absence of tumor suppressor gene Lumican mRNA may play an important role in the tumorgenesis and influences the prognosis of gastric cancer.