Immunogenicity of Vi capsular polysaccharide vaccine evaluated for three years in Korea
Journal of Korean Medical Science
;
: 314-317, 1995.
Artigo
em Inglês
| WPRIM
| ID: wpr-54556
ABSTRACT
The immunogenicity of a single dose of Salmonella typhi(S.typhi) Vi capsular polysaccharide(CPS) vaccine was evaluated before, and at 1, 3, 12, and 36 months after vaccination. Eighty-five adults(20-28 years of age) and sixty-four children(8-16 years of age) received a single dose of 25 micrograms Vi CPS vaccine intramuscularly, and antibody titers to Vi CPS were measured by passive hemagglutination. Of 149 vaccinees, 138(92.6%) showed seroconversion at 1 month after vaccination, and then 138 out of 141(97.9%) did at 3 months. Of 137 vaccinees, 116(84.7%) maintained a persistent rise in Vi antibody titer 12 months after vaccination, and 55 out of 100(55.0%) had a 4-fold or greater rise at 36 months. No significant adverse reactions were observed. Booster injection may be needed 3-5 years after vaccination.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polissacarídeos Bacterianos
/
Salmonella typhi
/
Febre Tifoide
/
Vacinas Tíficas-Paratíficas
/
Estudo de Avaliação
/
Anticorpos Antibacterianos
/
Antígenos de Bactérias
Limite:
Adolescente
/
Adulto
/
Criança
/
Humanos
Idioma:
Inglês
Revista:
Journal of Korean Medical Science
Ano de publicação:
1995
Tipo de documento:
Artigo
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