Significance of monoamine oxidase B activity in neurodegenerative models / 重庆医科大学学报

ABSTRACT

Objective:To investigate the changes of monoamine oxidase B(MAO B)activity in variety of neurodegenerative animal models and to discuss their significance.Methods:The neurodegenerative models were built with NIH male mice by means of the cerebral ischemia-reperfusion,aluminum overloading and carbon monoxide intoxication,respectively.The learning and memory ability of mice,MAO B activity of brain homogenates,and pathomorphological changes of hippocampal slices were determined using Morris maze and Step-down tests,MAO B kit,as well as microscopic observation with HE stain.Result:Although the significantly decreasing learning and memory ability and loss and karyopyknosis of hippocampal neurons were observed in three groups of animal models,compared with control group,the changes of MAO B activity were quite different.There was no significant change in cerebral ischemia-reperfusion model,but the unusual elevation was found in both aluminum overloading model and carbon monoxide intoxication model.Conclusion:The abnormal increase of MAO B does not occur in a variety of neurodegenerative animal models,which may indicate that the cerebral ischemia-reperfusion model can be used in the research of dementia and aluminum overloading model and carbon monoxide intoxication model can be used in the research of both dementia and extrapyramidal disease.