The clinicopathologic characters and prognosis of cervical cancer in 831 young women under 35 years old / 中国癌症杂志

ABSTRACT

Background and purpose:Several prior studies have evaluated that the overall incidence of cervical cancer has decreased in the past 30 years, while it seems that the age of mortality is younger, especially young women under 35 years old. The prognosis of cervical cancer in young women still needs to be determined. The purpose of this study was to determine the main clinicopathologic characteristics of cervical cancer in young women aged under 35 years and the influence of age on prognosis. Methods:A retrospective review was performed for 831 patients under 35 years old , 1 737 cases over 35 years old was used as a control group. Clinical and pathologic variables including clinical stage, pathological type, tumor size, lymph node metastases(LNM),depth of invasion(DI) and lymphovascular space involvement (LVSI)were analyzed using Peason chi-squowe test. The 5-year survival and 2-year recurrence rates were analyzed by Kaplan-Meier method.Results:The younger patients were characterized by a higher rate of early stage with 64% vs 37.8% in control group(P=0.000),non-squamous cell carcinoma were 14.90% in the study group and 6.80% in the control group(P=0.000),bulky lesion were 52.00% vs 30.44%(P=0.000), LNM were 33.46% vs 23.93% (P=0.000),deep stroma invasion(DSI) were 51.88% vs 39.94% (P=0.005),There was no significant difference in LVSI for two groups with 37.03% in the young group and 38.26% in the control group (P=0.663).The clinical stage and tumor size of young patients were related with LNM,DI and LVSI(P