1H-MRS in frontal lobe and hippocampus of patients with first episode major depression / 西安交通大学学报(医学版)
Journal of Xi'an Jiaotong University(Medical Sciences)
;
(6)1981.
Artigo
em Chinês
| WPRIM
| ID: wpr-546168
ABSTRACT
Objective To measure metabolism in brain of first episode major depression patients with 1H-MRS.Methods Single-voxel proton magnetic resonance spectroscopic(1H-MRS) examination of bilateralis frontal lobe and hippocampus was conducted in 23 patients with first episode major depression and 23 age-,sex-and education-matched healthy controls.We examined the metabolism such as NAA,Cho,Cr,Glx and mI in bilaterlis frontal lobe and hippocampus of patients.Results Bilateralis frontal lobe NAA/Cr,right frontal lobe Glx/Cr and left hippocampus NAA/Cr and Glx/Cr were significantly lower in MD patients versus controls,but right frontal lobe and right hippocampus mI/Cr significantly higher than in controls.Conclusion Nerve cell activity disorder,abnormal second messenger and glutamicacid and glutamine may be involved in the pathogenesis of major depression.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Journal of Xi'an Jiaotong University(Medical Sciences)
Ano de publicação:
1981
Tipo de documento:
Artigo
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