Effect of Formaldehyde Inhalation on Mice's Learning and Memory / 环境与健康杂志

ABSTRACT

Objective To study the effect of inhaling formaldehyde on learning and memory in mice. Methods 24 KM mice were randomly divided into four groups the control group (clean air),the low dose group (1 mg/m3),the moderate dose group (3 mg/m3) and the high dose group (5 mg/m3). The mice were exposed to different concentrations of gaseity formaldehyde,2 h/day,for 14 consecutive days. Then their behavior of learning and memory were tested by step-down test,passive avoidance test and Morris water maze experiment. Results Step-down test showed that the mice in the moderate dose group and the high dose group made notable errors compared with the control group (P