Expression and significance of epidermal growth factor receptor variant Ⅲ in human suprarenal epithelioma / 西安交通大学学报(医学版)

ABSTRACT

Objective To detect expression of epidermal growth factor receptor variant Ⅲ (EGFRvⅢ) in human suprarenal epithelioma to explore its relation with the genesis and development of suprarenal epithelioma.Methods Immunohistochemistry and pathologic image analysis were used to semiquantitatively detect the expression of EGFRvⅢ protein in eighty human suprarenal epithelioma tissues and twenty-four normal renal tissues.Results Positive expression rate of EGFRvⅢ was 46% in human suprarenal epithelioma tissues and 8% in normal renal tissues.Their average gray scale values were 148.49?13.05 and 155.65?14.86,respectively,which showed a significant difference (t=2.13,P=0.04).There was no obvious difference between males and females (149.01?13.70 and 147.40?11.76,t=0.54,P=0.59).No significant association was observed between EGFRvⅢ expression and age (r=0.01,P=0.92).Conclusion Many human suprarenal epithelioma tissues express EGFRvⅢ.EGFRvⅢ may play certain role in the genesis and development of human suprarenal epithelioma.