Differences in lymphocytes and the expression of FasL,ICAM-1 in the tonsillar HEVs associated with IgA nephropathy and recurrent tonsillitis / 中国免疫学杂志
Chinese Journal of Immunology
;
(12)2001.
Artigo
em Chinês
| WPRIM
| ID: wpr-546836
ABSTRACT
Objective:
To investigate the difference in expression of FasL and ICAM-1 in the tonsillar HEV associated with IgA nephropathy (IgAN) and recurrent tonsillitis (RT).Methods:
Human tonsils were obtained from the patients with RT (n=18) or IgAN (n=12).HE staining was used to show the morophometry of the tonsillar HEV.CD20+,CD3+ lymphocytes and distribution of FasL and ICAM-1 in the HEV were observed with immunohistochemical stained tissue section.The quantitatively experimental data from pathological image analysis were compared between IgAN and RT group.Results:
(1)The expressing intensity of ICAM-1 was (0.435 5?0.002) in IgAN group and (0.239 5?0.010 4) in RT group,respectively (P0.05).Conclusion:
A significant increase in the number of tonsillar HEV and increased lymphocytes in HEVs may indicate the abnormalities in peripheral blood in the patients with IgAN,thus leading to an overactivation of the tonsillar HEVs that induce Fas-dependent apoptosis in such patients.A stronger biological effective adhesion molecule promotes the transendothelial migration of lymphocytes across HEVs of palatine tonsil,which appears to be connected with the development of IgAN.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Immunology
Ano de publicação:
2001
Tipo de documento:
Artigo
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