THE EFFECTS OF SULMAZOLE ON HEMODYNAMICS IN ANESTHETIZED OPEN CHEST CATS / 第二军医大学学报

ABSTRACT

A new positive inotropic agent, sulmazole (base or HC1, l mg/kg i.v) increased dp/dtmax and LVSP significantly in anesthetized open chest cats (Ac) and acute heart failure cats (Fc).HR was increased minimally. The dp/dtmax values were increased by 7% (base, Ac), 13% (HC1, Ac), and 45% (base, Fc) respectively. In addition, sulmazole decreased LVEDP, and increased CO and MAP in Fc, while it lowered MAP in a dose-dependent manner (Ac).The lowest doses of sulmazole induced arrhythmia were 10 mg/kg i.v (Ac), and 20 mg/kg i.v (Fc), and the arrhythmia was reversible. When the dose was increased to 30mg/ kg i.v (base), severe arrhythmia could be produced in most cats.The ratio between toxic dose and effective dose was 10-30.Ouabain, 30 ?g/kg i.v, increased dp/dtmax, LVSP and MAP, and decreased HR significantly i Ac. Ouabain, 60 ?g/kg i.v, produced severe irreversible arrhythmia and most cats died (n = 6/8). The ratio between toxic and effective dose was less than 2.