Anti-SH2-B? antibody reduces the airway inflammation and hyperresponsiveness in a murine model of asthma / 中国免疫学杂志

ABSTRACT

Objective:To study the effect of SH2-B? on asthma.Methods:After inhibition of SH2-B?,the cells in the bronchoalveolar lavage fluid(BALF) were counted,and IL-4 and IgE in BALF,sera and culture supernants of spleen cells were measured by means of ELISA.The changes of the airway resistance and lung function were analyzed by means of animal lungs function analysis system.Results:Compared with that of the asthmatic group,1)Airway resistance to methacholine(MCh) was decreased significantly in anti-SH2-B? group(P