Oxidative Damage of Respiratory System in Rats Exposed to Carbon Nanotubes / 环境与健康杂志

ABSTRACT

Objection To explore the oxidative damage of respiratory system in rats exposed to carbon nanotubes(CNTs) . Methods Twelve Wistar rats were randomly divided into two groups(the treated group and the control group) and exposed to CNTs through intratracheal instillation at the dose of 22.5 mg/kg(calculated with CNTs) once a day for 15 days,then the rats were sacrificed,the biochemicaly indexes in serum and bronchoalveolar lavage fluid(BLAF) were measured. Results The results showed that CNTs could cause decrease of body weight gain,even after three days of stoping exposure to CNTs. Compared with the control group,the activity of superoxide dismutase(SOD) and total antioxidant capacity(T-AOC) in serum and BLAF of exposed rats decreased,the level of malondialdehyde(MDA) in serum and BLAF increased significantly. Conclusion CNTs exposure can induce the decrease of the antioxidant capacity and oxidative damage of respiratory system in rats.