Protective Effect of Aminoguanidine on Pancreatic Islet in Rats / 中国普外基础与临床杂志
Chinese Journal of Bases and Clinics in General Surgery
;
(12)2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-548025
ABSTRACT
Objective To investigate the effect of inducible nitric oxide synthase(iNOS) inhibitor aminoguanidine on pancreas islets cultured with cytokines TNF-? and IL-1? in rats.Methods Islets isolated from Wistar rats were purified and cultured.According to whether cytokines TNF-?,IL-1? and aminoguanidine were added into the medium respectively or not,islets were divided into 4 groups cultured with islet only was taken as blank control group,cultured with TNF-?+IL-1? as cytokine group,cultured with aminoguanidine as aminoguanidine group,and cultured with TNF-?+IL-1? and aminoguanidine as aminoguanidine+cytokine group.NO level in culture medium and iNOS activity in islets tissue(Test Kit),apoptosis(TUNEL method) and viability of islets cell(acridine orange/ethidium bromide stain),and the function of islets(insulin release test) were measured.Results Compared with blank control group,the activity of iNOS in islet tissue and level of NO in culture medium increased,and the mass mortality and apoptosis appeared in islet cells,while insulin secretion decreased in cytokine group(P
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Bases and Clinics in General Surgery
Ano de publicação:
2008
Tipo de documento:
Artigo
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