Effect of Complex Environment Stimulus on the Plasma Endothelin and Nitric Oxide in Rabbits / 环境与健康杂志

ABSTRACT

Objective To explore the environmental factors change on the plasma endothelin(ET) and nitric oxide(NO) in rabbits exposed to a complex environment:high temperature,hunger,and so on.Methods Ninety China rabbits were randomly divided into myocardial ischemia group,myocardial ischemia and hypoxia and high temperature group,myocardial ischemia and hypoxia group,myocardial ischemia and hunger group,myocardial ischemia and hypoxia and high temperature and hunger group,hunger group,hypoxia group,high temperatures group,control group,ten rabbits in each group.The animal myocardial ischemia was caused by fulgurating the left anterior descending branch artery in the heart.The animal hypoxia was caused by breathing in 8.5% nitrogen oxygen atmosphere(nitrogen content was 91.5%,oxygen content was 8.5%).The animals in the high temperature group were put into a high temperature [(42?2)℃] environment.The animals in the hunger group were treated with fasting and water deprivation for 24 h.Every animal has been taken in above-mentioned experiment environment for 30 min.Blood from jugular veins collected,and the contents of plasma ET and NO were determine.Results Compared with control group,except the hunger group and high temperature group,ET levels in the others six group were significantly increased(P