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Effect of resveratrol combined with DDP on FRH-0201 cholangiocarcinoma cell line / 中国现代普通外科进展
Chinese Journal of Current Advances in General Surgery ; (4)2009.
Artigo em Chinês | WPRIM | ID: wpr-548217
ABSTRACT
Objcetive To investigate the effect of resveratrol (RES)combined with cisplatin (DDP)on the cholangiocarcinoma cell line FRH-0201 in vitro.

Methods:

FRH-0201 cells were exposed to different concentrations of RES or (and)DDP. Cell morphological changes were observed by light and fluorescence microscopy. Inhibition of cell proliferation was measured by MTT and colony-forming assay. And the flow cytometry were performed to detect the cell apoptosis rate and cell cycle.

Results:

Resveratrol inhibited the proliferation of FRH-0201 cells in a time-and dose-dependent manner in the concentration of 5~320 ?mol/L and the IC50 values after the exposure of 24, 48, and 72 h were 55.35, 32.84, and 28.01 ?mol/L respectively. RES and DDP had synergetic effect in the inhibition of FRH-0201 cells.

Conclusion:

RES can inhibit the growth of FRH-0201 cells and has the synergetic effect with DDP.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Current Advances in General Surgery Ano de publicação: 2009 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Current Advances in General Surgery Ano de publicação: 2009 Tipo de documento: Artigo