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Effect and mechanism of Ghrelin on the colonic motility of diabetic mice / 中国现代普通外科进展
Chinese Journal of Current Advances in General Surgery ; (4)2004.
Artigo em Chinês | WPRIM | ID: wpr-548679
ABSTRACT

Objective:

To investigate colonic motility effect and mechanism of Ghrelin in diabetic mice.

Methods:

In vivo,the effects of Ghrelin(50,100,200 ?g/kg)on colonic transit of diabetic mice were measured by charcoal suspension pushing test.The effects of Atropine,N?-nitro-L-arginine methylester hydrochloride(L-NAME)and D-Lys3-GHRP-6(GHS-R antagonist)on the colonic transit of Ghrelin(200 ?g/kg)were also investigated.In vitro,the effects of Ghrelin on spontaneous contraction of proximal colonic circular muscle strips of diabetic mice were studied.

Results:

Ghrelin accelerated colonic transit of diabetic mice with significant dose-response relationship(P

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Current Advances in General Surgery Ano de publicação: 2004 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Current Advances in General Surgery Ano de publicação: 2004 Tipo de documento: Artigo