Immune escape mediated by myeloid-derived suppressor cells in hepatocarcinoma mice / 中国免疫学杂志

ABSTRACT

Objective:The changes and distribution of myeloid-derived suppressor cells (MDSCs) in spleen of tumor-bearing mice was studied,and its function in tumor escape was investigated.Methods:Orthotopic transplantation tumor model of hepatocarcinoma in mice was established.At the 7th,14th,21st day after tumor implantation,the proportion of MDSCs in spleen was tested by flow cytometry.The localization of MDSCs and semi-quantitative analysis was conducted by immunohistochemistry.Results:The proportion of spleen MDSCs in tumor-bearing mice was significantly higher than in normal mice (P