A STUDY OF THE ACTIVATION COEFFICIENTS OF BLOOD GLUTATHIONE REDUCTASE IN THE EVALUATION OF EXPERIMENTAL RIBOFLAVIN DEFICIENCY / 营养学报

ABSTRACT

From a study of the experimental riboflavin depletion in rats, it was demonstrated that the activation coefficients (AC) of the blood glutath-ione reductase (BGR) could be used to assess the riboflavin nutritional status of the animal. One week after deficiency the AC values were elevated, while after repletion of riboflavin they returned to normal. The change of AC values appeared sooner than that of daily excretions of riboflavin in urine. So AC value of BGR seemed to be a sensitive index in detecting early riboflavin deficiency. The method of the determination of AC value of BGR was modified so that only 0.02 ml. of whole blood was needed. It is rather convenient when used in field nutritional surveys.