An Ultrastructural Study of Renal Tissues with Experimenta Crush Syndrome in Rabbits / 第三军医大学学报

ABSTRACT

Experimental crush syndrome was inflicted to the kidneys of rabbits and specimens of renal tissues were studied with electron microscope. It was found that apart from the damage to the renal tubules, the ultrastructural alterations of the glomeruli were also prominent and were characterized as follows(1) Hypertrophy and hyperplasia of the glomerular cells resulting in narrowing and/or obliteration of the capillary loops.(2) Retrogressive changes of the glomerular cells in varying degrees such as mitochondrial swelling, dilatation of ER, vacuole formation, etc.On the basis of the morphological findings of the renal tissues in association with the clinical manifestations of acute renal failure (ARF), it is proposed that in addition to the damage of the renal tubules, a reduction of the glomerular filtration rate, which is the result of the altered hemodynamics in the renal vessels and the ultrastructural changes of the glomerular cells also play an important role in the pathogenesis of ARF.