Overexpression of Neuron-Specific Enolase as a Prognostic Factor in Patients with Gastric Cancer
Journal of Gastric Cancer
;
: 228-236, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-54932
ABSTRACT
PURPOSE:
Enolase is a cytoplasmic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in the glycolytic pathway. The aim of this study was to investigate whether the overexpression of neuron-specific enolase (NSE) can serve as a prognostic factor in patients with gastric cancer (GC). MATERIALS ANDMETHODS:
To assess its prognostic value in GC, NSE expression was measured by immunohistochemistry in a clinically annotated tissue microarray comprising of 327 human GC specimens. Cytoplasmic NSE expression was scored from 0 to 4, reflecting the percentage of NSE-positive cells.RESULTS:
In terms of histology as per the World Health Organization criteria (P=0.340), there were no differences between the NSE overexpression (NSE-OE) and NSE underexpression (NSE-UE) groups. The NSE-OE group showed a significantly lower rate of advanced GC (P<0.010), lymph node metastasis (P=0.010), advanced stage group (P<0.010), cancer-related death (P<0.010), and cancer recurrence (P<0.010). Additionally, a Kaplan-Meier survival analysis revealed that the NSE-OE group had longer cumulative survival times than the NSE-UE group (log-rank test, P<0.010). However, there were no significant differences in the serum levels of NSE expression in patients with GC and healthy volunteers (P=0.280).CONCLUSIONS:
Patients with NSE overexpressing GC tissues showed better prognostic results, implying that NSE could be a candidate biomarker of GC.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fosfoenolpiruvato
/
Fosfopiruvato Hidratase
/
Prognóstico
/
Recidiva
/
Neoplasias Gástricas
/
Organização Mundial da Saúde
/
Imuno-Histoquímica
/
Citoplasma
/
Voluntários Saudáveis
/
Linfonodos
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Journal of Gastric Cancer
Ano de publicação:
2017
Tipo de documento:
Artigo
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