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External Validation of a Gastric Cancer Nomogram Derived from a Large-volume Center Using Dataset from a Medium-volume Center
Journal of Gastric Cancer ; : 204-211, 2017.
Artigo em Inglês | WPRIM | ID: wpr-54935
ABSTRACT

PURPOSE:

Recently, a nomogram predicting overall survival after gastric resection was developed and externally validated in Korea and Japan. However, this gastric cancer nomogram is derived from large-volume centers, and the applicability of the nomogram in smaller centers must be proven. The purpose of this study is to externally validate the gastric cancer nomogram using a dataset from a medium-volume center in Korea. MATERIALS AND

METHODS:

We retrospectively analyzed 610 patients who underwent radical gastrectomy for gastric cancer from August 1, 2005 to December 31, 2011. Age, sex, number of metastatic lymph nodes (LNs), number of examined LNs, depth of invasion, and location of the tumor were investigated as variables for validation of the nomogram. Both discrimination and calibration of the nomogram were evaluated.

RESULTS:

The discrimination was evaluated using Harrell's C-index. The Harrell's C-index was 0.83 and the discrimination of the gastric cancer nomogram was appropriate. Regarding calibration, the 95% confidence interval of predicted survival appeared to be on the ideal reference line except in the poorest survival group. However, we observed a tendency for actual survival to be constantly higher than predicted survival in this cohort.

CONCLUSIONS:

Although the discrimination power was good, actual survival was slightly higher than that predicted by the nomogram. This phenomenon might be explained by elongated life span in the recent patient cohort due to advances in adjuvant chemotherapy and improved nutritional status. Future gastric cancer nomograms should consider elongated life span with the passage of time.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Neoplasias Gástricas / Calibragem / Estado Nutricional / Estudos Retrospectivos / Estudos de Coortes / Quimioterapia Adjuvante / Nomogramas / Discriminação Psicológica / Conjunto de Dados / Gastrectomia Tipo de estudo: Estudo de etiologia / Estudo de incidência / Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Humanos País/Região como assunto: Ásia Idioma: Inglês Revista: Journal of Gastric Cancer Ano de publicação: 2017 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Neoplasias Gástricas / Calibragem / Estado Nutricional / Estudos Retrospectivos / Estudos de Coortes / Quimioterapia Adjuvante / Nomogramas / Discriminação Psicológica / Conjunto de Dados / Gastrectomia Tipo de estudo: Estudo de etiologia / Estudo de incidência / Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Humanos País/Região como assunto: Ásia Idioma: Inglês Revista: Journal of Gastric Cancer Ano de publicação: 2017 Tipo de documento: Artigo