THE EFFECT OF DYNORPHIN A-(1-13)ON IMMUNGREACTIVE SUBSTANCE P CONTENT IN SPINAL CORD AND ITS INTERACTION WITH THE EFFECT OF MORPHSNE / 第二军医大学学报

ABSTRACT

The interactive effects of dynorphin A-(1-13)and morphine on immunoreactive substance P(ir-sp)content in spinal cord of mice were investigated by means of radi-oimmunoassay.The spinal cord ir-sp content was apparently increased by morphine administration s.c.(5mg/kg). Dynorphin A-(1-13)injection i.c.v.also elevated the spinal cord ir-sp content in a dose-dependent fashion.The effect of dynorphin A-(1-13)plus morphine in low doses(5?g, 10?g)was similar to that of either morphine or dynophin A-(1-13)alonc .However, the effect of combinating high doses(20?g, 40?g)of dynorphin A-(1-13)with morphine showed much lesser than that of morphine or dynorphin A-(1-13)did alone.