Interrelationship between the Contents of Thromboxane and Prostacyclin in Plasma and Lung Tissue in ARDS in Rabbits / 第三军医大学学报

ABSTRACT

This study was designed to investigate the changes of the contents of throm-boxane (TXA2) and prostacyclin (PGI2) in the pulmonary tissue and in the plasma of the pulmonary arteries and left atrium of the rabbits during ARDS induced with oleic acid injection and the interrelationship between the two substances.The contents of TXA2 and PGI2 were determined indirectly,by measuring the amounts of TXB2 and 6-keto-PGF1a,the stable metabolites of TXA2 and PGI2 respectively,with radioimmunoassay.After an injection of oleic acid to the rabbits (0.045ml/kg),the contents of TXB2 in both the plasma and lung tissue were significantly elevated The content of 6-keto-PGF1a in the plasma significantly increased at 30 minutes and reached the highest point at 180 minutes after the injection,and that in the lung tissue began to increase at 5 minutes and reached the peak at 60 minutes after injection The ratio of TXB2/6-keto-PGI18 increased in the early stage after injection and then reduced both in the plasma and the lung tissue.The results indicate that the contents of TXA2 and PGI2 in the plasma are not always parallel with those in the lung tissue,which suggests that the variation of the ratio of TXA2/PGI2 may play an important role in the pathogenesis of ARDS.