STUDIES ON THE ANIMAL MODEL OF ACUTE IMPAIRED PIAL MICROCIRCULATON / 第二军医大学学报

ABSTRACT

In this study, the animal model of acute impaired pial microcirculation was stablished by intravenous injection of dextran of high molecular weight. The manifestations of the animal model of acute impaired pial microcirculation were as follows blood flow in the pial microvessles was slowed down and presented granular or cotton-like pattern, and erythrocyte aggregation occurred.Ninety-eight rabbits were divided into group A (38 rabbits) and group B (60 rabbits).Solution of dextran with an average molecular weight of 25x104 dalton was used in group A and the animal model of acute impaired pial microcircuiation was established in 28 of 38 rabbits, and the successful duplication rate of animal models was only 73.6%.However, solution of dextran with an avera molecular weight of 49x104 dalton was used in group B and the model of acute impaired pial microcirc-ulatiori was established in 59 of 60 rabbits with a duplication rate of about 98.3%. The experimental results suggest that the dextran with an average molecular weight of 49x104 dalton was better than the dextran with an average molecular weight of 25x104 in producing the animal model of acute impaired pial microcirculation. The animal model can be used in the research on the impaired pial microcirculation and agents for improving pial microcirculation.