A NONLINEAR FITTING METHOD AND STATISTICAL EVALUATION FOR DETERMINING PHARMACOKINETIC PARA-METERS WITH MICROCOMPUTER / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12)1986.
Artigo
em Chinês
| WPRIM
| ID: wpr-549465
ABSTRACT
In calculating pharmacokinetic parameters, Subjective bias may be induced by using the method of residuals. This paper reports a nonlinear least squares fitting program which may be adapted in APPLE II microcomputer. The program can not only increase the precision of estimated parameters, but also provide objective criteria e.g. Akaike's Information Criterion ( AIC ) for determining which kind of compartment model is most appropriate. Furthermore, the standard error of parameter is calculated which gives the variability of the estimation. The use of this program is guided on-screen prompts that display Some form of menu including the various types of compartmental models for intra and extravascular administration. The data can be stored or drawn out from the disk and the plot of curve fitting is readily feasible.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Chinese Pharmacological Bulletin
Ano de publicação:
1986
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS