THE EFFECT OF TGPs ON CADIOVASCULAR SYSTEM / 中国药理学通报

ABSTRACT

The total glucosides of Paeony root ( TGPs ) extracted from Anhui Boxian Paeonia lactiflora Pall can dialet the vessels of rabbit's ears in vitro and increased both the number of drops and the volume (ml) per minute. TGPs had no definite effects on the isolated aorta strips of rabbits directly, but it significantly increased the contraction of aorta strips induced by NA. In vivo, TGPs raised the diasto-lic pressure (which could not be blocked by phentolamine) , and increased the dp/dtmax and decreased the heart rate. TGPs also strengthened the effect of raising the blood pressure and increasing the heart sound intensity induced by NA. The results about the blood pressure and heart function studied on cats were almost the same as on rabbits