Effects of Calcium Gluconate on Cardiovascular Functions, Oxygen Transport and Acid-base Balance during Hemorrhagic Shock in Dogs / 第三军医大学学报

ABSTRACT

Hemorrhagic shock was induced in 13 dogs with modified Wigger's method to maintain the mean arterial pressure at 5.33kPa for 60 minutes. 6 dogs were treated with 10% calcium gluconate 0.15ml/kg intravenously at the 60th, 70th, and 80th minute of the oligemic period respectively, while 7 dogs received an equal volume of normal saline at the corresponding time. At the 90th minute of the oligemic period, the shed blood was transfused back to the animals.During the 90-minute oligemic shock period, the mean arterial pressure, the peak value of the left ventricle systolic pressure, + dp/dtmax and total peripheral resistance of the treated dogs were significantly higher than those of the controls, but the heart rate, cardiac index, - dt/dtmax and myocardial oxygen consumption showed no significant difference between the 2 groups. After the transfusion of the shed blood back to the animals, no apparent difference of any of the above-mentioned parameters between the 2 groups could be found. In both groups, the oxygen delivery, oxygen consumption, oxygen extract ration and pH value were similar during the oligemic period and after the back-transfusion of the shed blood.The results indicate that exogenous calcium infusion cannot bring about any beneficial effects on the cardiovascular functions, oxygen transport and acid-base balance during hemorrhagic shock.