HYPERBARIC OXYGEN THERAPY OF ACUTE COMPARTMENT SYNDROME AND THE RELATIONSHIP BETWEEN PLASMA FIBRONECTIN CONCENTRATION AND PROGNOSIS / 第二军医大学学报

ABSTRACT

This report describes for the first time the effect of hyperbaric oxygen therapy at 253 kPa on post-trauma acute compartment syndrome in 24 patients and the relationship between the prognosis of the syndrome and the changes of plasma fibronectin.Plasma fibronectin was measured using single radial immunodiffusion before and after the therapy and 30 healthy subjects were used as controls.The results showed that clinical symptoms and signs of 16 patients with acute compartment syndrome at the early stage were significantly improved after 3-5 times of hyperbaric oxygen therapy and recovered without performing fasciotomy; infection, edema and swelling of the injuried limbs and temperature were markedly reduced in 6 patients treated with hyperbaric oxygen after fasciotomy, and no good therapeutic efficacy was obtained in 2 patients at the necrotic stage although their clinical symptoms and signs were partially improved.It was also found that plasma fibronectin concentrations were significantly increased in these patients after hyperbaric oxygen therapy.The mean increase was 47(18.9%, P