Effect of Anisodamine on Treatment of the Experimental Respiratory Distress Syndrome (RDS) in Dogs / 第三军医大学学报

ABSTRACT

The respiratory distress syndrome (RDS) model induced by oleic acid injection in dogs and treated by anisodamine were observed. The blood gas parameters, pulmonary arterial pressure, pulmonary wedge pressure, blooe cell count, neutrophil aggregation, platelet aggregation activation, thromboxane B2, 6-keto-PGF1? and hemocoagulograms were studied in order to determine the pathophy-siological mechanism and the effect of auisodamine. The complement activation and neutrophil aggregation induced by C3a and thromboxane A2 are likely the initiation factors of RDS; lung injuries were complicated with disseminated intravas-cular coagulation and anisodamine exerts certain therapeutic effect on RDS.