OBSERVATION ON ACUTE TOXICITY OF RADIOSENSITIZERS CMCa IN DOGS / 第二军医大学学报

ABSTRACT

Metronidazole derivative CMCa is a kind of radiosensitizers to tumor hypoxic cells. It can highly concentrated in cancer tissues. Acute toxicity assay revealed that ALD was 3.43 g/kg and MLD was 4.0g/kg. No significant changes in clinical symptoms, blood pictures and hepatorenal function were found at small dose (1g/kg), but at middle dose (2 g/kg) nausea and vomiting might occur but not significant in laboratory findings. However at larger dose (4.0 g/kg) the G-I and CNS symptoms were marked, and the cause of death was DIC. So, it can not be used in clinically at this dosage. Owing to the unstability of CMCa it should be prepared freshly before usage.