An Experimental Study of Pathogenesis of Acute Lung Injury Induced by Complement Activation in Conscious Goat, Roles of Leukocytes and Prostaglandins / 第三军医大学学报

ABSTRACT

The roles of leukocytes and prostaglandins in mediating alterations of pulmonary hemodynainics and lung fluid exchange after intravenous autologous zymo-san-activated plasma (ZAP) challenge is investigated in 14 conscious goats with chronic lung-lymph-fistula. In the control group, ZAP infusion causes the mean pulmonary arterial pressure (Ppa) markedly elevate, lung lymph flow (QI) and the lymph-to-plasma protein concentration ratio (L/P) increase. There is a significant correlation between Ppa and the content of plasma TXB2. In antiPMNs serum-induced leukopenia group, the extent of increment in Pp a is not as obvious as the normal goats, and no marked change is observed in QI, L/P and content of TXB2. These results indicate l.TXA2 releases from leukocytes may affect lung fluid exchange during ZAP infusion; 2. leukocytes may play an important role in ZAP-induced lung injury.